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Central\u4e0a\u7684\u4e9a\u6d32\u4eba\u7fa4CO2\u70b9\u9635\u6fc0\u5149\u7814\u7a76\uff0c\u7528\u4eea\u5668\u6d4b\u91cf\u4e86\u6cbb\u7597\u524d\u540e\u7684\u7ecf\u76ae\u6c34\u5206\u6d41\u5931(TEWL)\u6307\u6807\u3002\u7ed3\u679c\u663e\u793a\u76ae\u80a4\u5c4f\u969c\u5728\u6cbb\u7597\u540e\u4e00\u5468\u5185\u4ecd\u5904\u4e8e\u53d7\u635f\u72b6\u6001\uff0c\u7814\u7a76\u4f5c\u8005\u636e\u6b64\u63d0\u793a\u8fd9\u6bb5\u65f6\u95f4\u5b58\u5728\u5355\u7eaf\u75b1\u75b9\u6216\u6bdb\u56ca\u708e\u7b49\u611f\u67d3\u98ce\u9669\uff0c\u5efa\u8bae\u79ef\u6781\u4f7f\u7528\u76ae\u80a4\u4fee\u590d\u7c7b\u4ea7\u54c1\u548c\u4fdd\u6e7f\u5242\u3002\u8fd9\u6761\u65f6\u95f4\u7ebf\uff0c\u6b63\u662f\u6211\u4eec\u5224\u65ad&#8221;\u8868\u5c42\u6253\u5f00\u578b&#8221;\u7597\u7a0b\u8be5\u7b49\u591a\u4e45\u7684\u4f9d\u636e\u3002<\/p>\n<p>\u5fae\u901a\u9053\u95ed\u5408\u7684\u901f\u5ea6\u672c\u8eab\u8981\u5feb\u5f97\u591a\u3002\u56fd\u9645\u671f\u520a\u300aInternational Journal of Pharmaceutics\u300b2019\u5e74\u53d1\u8868\u7684\u4e00\u9879\u52a8\u7269\u5b9e\u9a8c\u53d1\u73b0\uff0c\u70b9\u9635\u956d\u5c04\u9020\u6210\u7684\u5fae\u901a\u9053\u5728\u7167\u5c04\u540e\u7ea616\u5c0f\u65f6\u65f6\u5c4f\u969c\u529f\u80fd\u5df2\u7ecf\u6062\u590d\uff0c\u4f46\u7814\u7a76\u540c\u65f6\u6307\u51fa\uff0c\u5373\u4fbf\u523016\u5c0f\u65f6\uff0c\u5fae\u5b54\u5728\u5149\u5b66\u663e\u5fae\u955c\u4e0b\u4ecd\u672a\u5b8c\u5168\u95ed\u5408\u3002\u8fd9\u9879\u7814\u7a76\u7528\u7684\u662f\u88f8\u9f20\u76ae\u80a4\uff0c\u80fd\u91cf\u53c2\u6570\u548c\u771f\u4eba\u9762\u90e8\u76ae\u80a4\u5e76\u4e0d\u5b8c\u5168\u4e00\u81f4\uff0c\u6211\u4eec\u53ea\u628a\u8fd9\u4e2a\u6570\u5b57\u5f53\u4f5c&#8221;\u5fae\u901a\u9053\u81f3\u5c11\u8981\u95ed\u5408\u534a\u5929\u4ee5\u4e0a&#8221;\u7684\u65b9\u5411\u6027\u53c2\u8003\uff0c\u5b9e\u9645\u7ed9\u5ba2\u4eba\u7684\u5efa\u8bae\u4f1a\u66f4\u4fdd\u5b88\u4e00\u4e9b\u3002<\/p>\n<h2>\u4e0d\u6253\u5f00\u8868\u5c42\u7684\u9879\u76ee\uff1a\u7f8e\u7248\u8d85\u58f0\u5200\u3001\u70ed\u739b\u5409\u3001\u7d22\u592b\u6ce2\u3001\u97e9\u7248\u70ed\u739b\u5409X<\/h2>\n<p>\u8d85\u58f0\u548c\u5c04\u9891\u7c7b\u63d0\u5347\u9879\u76ee\u628a\u80fd\u91cf\u9001\u5230\u771f\u76ae\u5c42\u4ee5\u4e0b\u6216\u7b4b\u819c\u5c42\uff0c\u8868\u9762\u7684\u89d2\u8d28\u5c42\u539f\u6837\u4fdd\u7559\u3002\u6cbb\u7597\u540e\u51fa\u73b0\u7684\u7ea2\u80bf\u548c\u53d1\u70ed\u611f\uff0c\u662f\u80fd\u91cf\u4f5c\u7528\u540e\u7684\u6b63\u5e38\u53cd\u5e94\uff0c\u4e0d\u4ee3\u8868\u8868\u5c42\u88ab\u6253\u5f00\u3002<\/p>\n<p>\u8fd9\u4e00\u7c7b\u53cd\u5e94\u7684\u6301\u7eed\u65f6\u95f4\u6709\u7efc\u8ff0\u6587\u7ae0\u53ef\u4ee5\u53c2\u8003\u3002\u5b66\u672f\u671f\u520a\u300aApplied Sciences\u300b(MDPI\uff0c2025\u5e74)\u520a\u8f7d\u7684\u4e00\u7bc7HIFU\u7f8e\u5bb9\u9879\u76ee\u5e76\u53d1\u75c7\u7cfb\u7edf\u7efc\u8ff0\u6307\u51fa\uff0c\u62a5\u544a\u7684\u5e76\u53d1\u75c7\u5927\u591a\u4e3a\u4e00\u65f6\u6027\u7ea2\u6591\u3001\u80bf\u80c0\u548c\u4e0d\u9002\u611f\uff0c\u901a\u5e38\u5728\u6570\u5c0f\u65f6\u5230\u6570\u5929\u5185\u81ea\u884c\u6d88\u9000\uff0c\u4e0d\u9700\u8981\u989d\u5916\u7684\u533b\u7597\u5904\u7406\u3002<\/p>\n<p>\u6211\u4eec\u8bca\u6240\u5bf9\u8fd9\u4e00\u7c7b\u9879\u76ee\u7684\u5b89\u6392\u662f\uff1a\u7ea2\u80bf\u660e\u663e\u671f\u95f4\u5148\u4e0d\u7528\u5237\u5b50\u6d82\u62b9\u7c89\u5e95\uff0c\u6539\u7528\u624b\u6307\u6216\u5e72\u51c0\u7684\u7c89\u6251\u8f7b\u8f7b\u6309\u538b\u4e0a\u5986\uff0c\u56e0\u4e3a\u6469\u64e6\u5bf9\u8fd8\u6709\u4f59\u70ed\u7684\u76ae\u80a4\u662f\u4e0d\u5fc5\u8981\u7684\u523a\u6fc0\u3002\u5982\u679c\u6cbb\u7597\u65f6\u914d\u5408\u4e86\u5c40\u90e8\u9ebb\u9189\u6ce8\u5c04\uff0c\u80bf\u80c0\u53ef\u80fd\u4f1a\u62d6\u5f97\u7a0d\u4e45\uff0c\u8fd9\u79cd\u60c5\u51b5\u5efa\u8bae\u5ef6\u5230\u7b2c\u4e8c\u5929\u518d\u5316\u3002<\/p>\n<h2>\u7559\u4e0b\u5fae\u901a\u9053\u7684\u9879\u76ee\uff1a\u5c11\u5973\u9488\u3001\u4e54\u96c5\u9732\u586b\u5145\u3001Skinvive\u3001\u9ec4\u91d1\u5fae\u9488<\/h2>\n<p>\u5c11\u5973\u9488\u3001\u4e54\u96c5\u9732\u586b\u5145\u3001Skinvive\u8fd9\u7c7b\u6ce8\u5c04\u9879\u76ee\uff0c\u4ee5\u53ca\u9ec4\u91d1\u5fae\u9488\u8fd9\u6837\u7684RF\u5fae\u9488\u6280\u672f\uff0c\u90fd\u4f1a\u5728\u76ae\u80a4\u4e0a\u7559\u4e0b\u771f\u5b9e\u7684\u5fae\u5c0f\u5b54\u9053\u3002\u5b54\u9053\u7684\u6df1\u5ea6\u3001\u6570\u91cf\u548c\u6ce8\u5c04\u7269\u7684\u9ecf\u7a20\u5ea6\uff0c\u51b3\u5b9a\u4e86\u7ea2\u80bf\u548c\u5fae\u80bf\u80c0\u4f1a\u6301\u7eed\u591a\u4e45\u3002<\/p>\n<p>\u8fd9\u65f6\u5019\u6025\u7740\u8865\u5986\u6709\u4e24\u4e2a\u95ee\u9898\u3002\u4e00\u662f\u8fd8\u6ca1\u5b8c\u5168\u95ed\u5408\u7684\u6ce8\u5c04\u70b9\uff0c\u5237\u5b50\u6216\u7c89\u6251\u4e0a\u7684\u7ec6\u83cc\u6709\u673a\u4f1a\u8fdb\u5165\uff1b\u4e8c\u662f\u4e0a\u5986\u9700\u8981\u7684\u6309\u538b\u529b\u9053\uff0c\u4f1a\u76f4\u63a5\u4f20\u5230\u8fd8\u6ca1\u7a33\u5b9a\u4e0b\u6765\u7684\u6ce8\u5c04\u7269\u4e0a\u3002<\/p>\n<p>\u56e0\u6b64\u6211\u4eec\u8bca\u6240\u5bf9\u8fd9\u4e00\u7c7b\u9879\u76ee\u7684\u5efa\u8bae\u662f\uff1a\u5f53\u5929\u4e0d\u4e0a\u8272\u5986\uff0c\u7b2c\u4e8c\u5929\u65e9\u4e0a\u518d\u5f00\u59cb\u3002\u5982\u679c\u5f53\u5929\u665a\u4e0a\u786e\u5b9e\u6709\u5fc5\u987b\u51fa\u5e2d\u7684\u573a\u5408\uff0c\u53ef\u4ee5\u5728\u4e0d\u76f4\u63a5\u8986\u76d6\u6ce8\u5c04\u90e8\u4f4d\u7684\u8303\u56f4\u5185\u5c11\u91cf\u8865\u5986\uff0c\u5e76\u4e14\u6362\u4e00\u4e2a\u6ca1\u7528\u8fc7\u7684\u7c89\u6251\u3002\u8c03\u6574\u7597\u7a0b\u987a\u5e8f\u4e5f\u662f\u4e00\u4e2a\u529e\u6cd5\uff0c\u6bd4\u5982\u628a\u5c11\u5973\u9488\u5b89\u6392\u5728\u56de\u56fd\u524d\u4e00\u5929\u4e0b\u5348\uff0c\u98de\u673a\u4e0a\u672c\u6765\u5c31\u4e0d\u9700\u8981\u5316\u5986\uff0c\u6062\u590d\u65f6\u95f4\u81ea\u7136\u5c31\u6709\u4e86\u3002<\/p>\n<p>\u8089\u6bd2\u6bd2\u7d20\u7684\u6ce8\u5c04\u70b9\u540c\u6837\u662f\u5fae\u5c0f\u5f00\u53e3\uff0c\u4f46\u5b54\u9053\u6d45\u800c\u5c0f\uff0c\u6062\u590d\u901f\u5ea6\u5feb\uff0c\u6bd4\u8d77\u5316\u5986\u65f6\u673a,\u66f4\u9700\u8981\u6ce8\u610f\u7684\u662f\u907f\u514d\u63c9\u6413\u548c\u6309\u538b\u9762\u90e8\u3002<\/p>\n<h2>\u8272\u7d20\u956d\u5c04\u548c\u5265\u8131\u7c7b\u956d\u5c04\uff0c\u7b97\u6cd5\u4e0d\u4e00\u6837<\/h2>\n<p>\u76ae\u79d2\u7c7b\u8272\u7d20\u956d\u5c04\u548c\u70b9\u9635\u5265\u8131\u7c7b\u956d\u5c04\uff0c\u8ddf\u4e0a\u9762\u4e24\u7c7b\u4e0d\u80fd\u7528\u540c\u4e00\u5f20\u65f6\u95f4\u8868\u3002\u8fd9\u7c7b\u9879\u76ee\u4f1a\u8ba9\u8868\u5c42\u7ec6\u80de\u6c7d\u5316\u6216\u5f62\u6210\u5fae\u5c0f\u7ed3\u75c2\uff0c\u7ed3\u75c2\u8131\u843d\u3001\u76ae\u80a4\u5b8c\u6210\u518d\u4e0a\u76ae\u5316\u624d\u7b97\u6062\u590d\u3002\u524d\u9762\u5f15\u7528\u7684\u90a3\u9879\u6d4b\u91cf\u7814\u7a76\u91cc\uff0c\u5c4f\u969c\u56de\u5230\u6cbb\u7597\u524d\u6c34\u5e73\u5927\u7ea6\u82b1\u4e86\u4e00\u5468\u65f6\u95f4\uff0c\u8bf4\u7684\u6b63\u662f\u8fd9\u4e2a\u9636\u6bb5\u3002<\/p>\n<p>\u8fd9\u4e2a\u9636\u6bb5\u7528\u7c89\u5e95\u76d6\u7ea2\u80bf\uff0c\u98ce\u9669\u662f\u4e24\u5c42\u53e0\u52a0\u7684\uff1a\u611f\u67d3\u98ce\u9669\u8fd8\u6ca1\u89e3\u9664\uff0c\u53c8\u52a0\u4e0a\u4e86\u5f02\u7269\u8986\u76d6\uff1b\u4e0a\u5986\u548c\u5378\u5986\u7684\u52a8\u4f5c\u8fd8\u4f1a\u5bf9\u7ed3\u75c2\u9020\u6210\u7269\u7406\u6469\u64e6\u3002\u5982\u679c\u5ba2\u4eba\u662f\u590f\u5929\u6237\u5916\u6d3b\u52a8\u6652\u9ed1\u540e\u6765\u505a\u8272\u7d20\u956d\u5c04\uff0c\u8fd8\u8981\u989d\u5916\u8003\u8651\u708e\u75c7\u540e\u8272\u7d20\u6c89\u6dc0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p>\u6211\u4eec\u5728\u7ed9\u77ed\u671f\u505c\u7559\u5ba2\u4eba\u5b89\u6392\u5265\u8131\u7c7b\u8272\u7d20\u9879\u76ee\u65f6\uff0c\u4e00\u5b9a\u4f1a\u628a\u56de\u56fd\u540e\u7684\u6062\u590d\u65f6\u95f4\u4e00\u5e76\u7b97\u8fdb\u884c\u7a0b\u8bbe\u8ba1\u3002\u5982\u679c\u5ba2\u4eba\u5728\u505c\u7559\u671f\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FLAT The 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CELL\u6c5f\u5357\u70b9\u7684\u91d1\u6e0a\u632f\u4ee3\u8868\u9662\u957f\u6bd5\u4e1a\u4e8e\u9996\u5c14\u5927\u5b66\u7814\u7a76\u751f\u9662\uff0c\u66fe\u5728\u9996\u5c14\u5927\u5b66\u533b\u9662\u5b8c\u6210\u4f4f\u9662\u533b\u57f9\u8bad\uff0c\u662fAllergan(\u4e54\u96c5\u9732\u3001\u4fdd\u59a5\u9002)\u7684faculty\u6210\u5458\uff0c\u4e5f\u662f\u9ec4\u91d1\u5fae\u9488\u548c\u7f8e\u7248\u8d85\u58f0\u5200\u7684Z Key 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