Rejuran vs Juvelook: Gangnam Dermatologist Explains

2026/03/26

  • rejuran

Among Korean aesthetic procedures, skin boosters have become a signature treatment that many people seeking skin improvement are interested in. In particular, domestic dermatology clinics introduce various types of skin booster products, and many people are confused about which procedure to choose. In this article, we will provide a detailed explanation of the characteristics and differences between Rejuran and Juvelook, two of the most popular skin booster products currently available, to help you select the procedure that best suits your skin condition.

What is a Skin Booster?

A skin booster is a procedure that directly injects active ingredients into the dermis layer of the skin using injection needles. Rather than simple surface treatment, it works by promoting hydration and collagen formation from within the skin. Recently, several products including Rejuran and Juvelook have been launched on the market, and each product has different active ingredients and mechanisms of action.

Key Characteristics and Effects of Rejuran

The main ingredient in Rejuran is polynucleotide, a DNA extract from salmon. This ingredient was initially developed in Korea for burn patients and those with severe inflammatory reactions, and is well-known for its excellent anti-inflammatory effects. Rejuran can help calm inflammation and improve skin redness, itching, and dryness.

Additionally, hyaluronic acid, which is commonly included in all skin boosters, is also contained in Rejuran, allowing you to expect hydration and improved moisture retention. A distinctive feature is that you can notice improvements in skin elasticity and radiance relatively quickly—right after the procedure, the next day, and within a week.

  • Active Ingredient: Salmon DNA extract (polynucleotide)
  • Primary Effect: Anti-inflammatory, reduces redness and dryness
  • Time to Results: Noticeable improvements immediately after treatment
  • Recommended For: Those with atopic dermatitis, sensitive skin, or seasonal dryness

Characteristics of Juvelook and Its Collagen Generation Mechanism

The main ingredient in Juvelook is polylactic acid, a polymer of lactic acid. These fine particles act as seeds for collagen formation in the dermis layer of the skin. You may not notice significant changes immediately after the procedure, but you can expect progressive improvements in skin texture as collagen is gradually generated over 2 weeks to 2 months and beyond.

Since the polylactic acid component in Juvelook eventually breaks down into water, the degradation process continuously generates moisture. Therefore, the product can provide long-lasting hydration effects as it gradually breaks down over 2 months to 1 year following the procedure. For this reason, it is highly effective for improving uneven acne scars and enlarged pores.

  • Active Ingredient: Polylactic acid (polymer of lactic acid)
  • Primary Effect: Promotes collagen generation, provides long-term hydration
  • Time to Results: Gradual improvements begin after 2 weeks
  • Recommended For: Acne scars, enlarged pores, uneven skin texture

Pain Comparison: Rejuran vs Juvelook

One of the most frequently asked questions by those considering skin boosters is about pain. Generally, Juvelook tends to cause less discomfort than Rejuran. However, this can vary depending on the clinic’s anesthesia method and product mixing technique. If experienced medical professionals properly incorporate anesthetic components into the mixture, the discomfort from Juvelook can be further minimized.

Many clinics consider the order of procedures important when administering both products simultaneously. If Juvelook is injected first and then Rejuran is applied to the same area, pain can be significantly reduced. Therefore, if you are sensitive to pain, we recommend informing your medical professionals during the consultation and requesting a procedure method tailored to your individual pain sensitivity.

Treatment Selection Guide Based on Skin Condition

For Sensitive, Red Skin or Seasonal Dryness

Rejuran is recommended for those with atopic dermatitis or those who experience severe flaking and redness during seasonal changes. The anti-inflammatory effects of the salmon DNA extract can help calm skin irritation, and hydration can help improve dryness.

For Acne Scar and Pore Improvement

Juvelook is recommended for those whose skin has become uneven and pores have enlarged after acne breakouts. The collagen-generating mechanism can be effective in improving skin texture. With multiple treatments, you can expect gradual and progressive improvement.

For Those Wanting Both Immediate and Long-term Results

Many clinics administer both Rejuran and Juvelook together. In this case, initially your skin improves immediately thanks to the quick effects of Rejuran, and over the medium to long term, the collagen-generating effects of Juvelook accumulate to provide sustained improvement.

Post-Treatment Side Effects and Precautions

Since skin boosters use injection needles, common injection-related side effects such as bruising, swelling, and bleeding may occur. Additionally, an “embossing effect” where the skin appears bumpy may appear for 1-2 days immediately after treatment. This is a normal response and will naturally improve over time.

If you have an important event or photo shoot scheduled, be sure to inform your medical professional during the consultation. Experienced medical professionals can minimize the embossing effect by adjusting the injection depth. They can also flexibly modify the treatment approach based on your skin condition and schedule.

Manual Injection vs Machine Injection

Skin boosters can be administered using two methods: manual injection and machine injection. The advantage of manual injection is that it is completed very quickly. For experienced medical professionals, the procedure can be completed within 1-2 minutes, making manual injection ideal if you want to finish your treatment in minimal time. Additionally, it minimizes waste so that precious medication is not lost.

The advantage of machine injection is that it causes less pain. However, the procedure takes approximately 7-10 minutes, so while the discomfort is reduced, the treatment duration is longer. Additionally, the medication can be distributed more homogeneously and thoroughly. We recommend experiencing both manual and machine injection methods before choosing the approach that works best for you.

Conclusion: Consultation with a Professional is Most Important

Rejuran and Juvelook each have their own advantages and characteristics, and there is no single “better” treatment option. What matters is receiving customized treatment by comprehensively considering your current skin condition, desired improvement goals, pain sensitivity, and schedule.

Medical professionals at excellent dermatology clinics do not simply recommend just one procedure. Rather, they conduct a precise diagnosis of your skin condition and propose the optimal treatment method and product combination for you. They also apply various expertise to minimize pain, including anesthesia methods, needle selection, and the order of procedures.

If you are considering a skin booster treatment, information found online alone may not be sufficient. We strongly recommend scheduling a personal consultation with a specialist dermatologist to find the treatment method best suited to your skin. An honest consultation with experienced medical professionals is the first step toward a successful procedure.

Source : https://youtu.be/5BmtHePyIuQ

UHCELL Dermatology Gangnam Branch (formerly Dr. Petite Clinic Dermatology Gangnam Branch)