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Central\u7684\u4e00\u7bc7\u7814\u7a76\u986f\u793a\uff0c\u98db\u68ad\u96f7\u5c04\u5f8c\u7d93\u76ae\u6c34\u5206\u6563\u5931\uff08TEWL\uff09\u660e\u986f\u4e0a\u5347\uff0c\u96a8\u5f8c\u9010\u6f38\u4e0b\u964d\uff0c\u7d04\u4e00\u9031\u5f8c\u56de\u5230\u8853\u524d\u6c34\u6e96\u3002\u7814\u7a76\u5718\u968a\u4e5f\u6307\u51fa\uff0c\u9019\u6bb5\u5c4f\u969c\u7f3a\u640d\u671f\u9593\u55ae\u7d14\u75b1\u75b9\u6216\u6bdb\u56ca\u708e\u7b49\u611f\u67d3\u98a8\u96aa\u53ef\u80fd\u589e\u52a0\uff0c\u5efa\u8b70\u7a4d\u6975\u4f7f\u7528\u6577\u6599\u8207\u4fdd\u6fd5\u7522\u54c1\u3002\u4ec0\u9ebc\u6642\u5019\u80fd\u91cd\u65b0\u4e0a\u599d\uff0c\u5c31\u662f\u843d\u5728\u9019\u689d\u66f2\u7dda\u4e0a\u7684\u5224\u65b7\u3002<\/p>\n<p>\u5fae\u5c0f\u901a\u9053\u9589\u5408\u7684\u901f\u5ea6\u5feb\u5f97\u591a\u3002\u570b\u969b\u671f\u520a\u300aInternational Journal of Pharmaceutics\u300b2019\u5e74\u520a\u767b\u7684\u4e00\u7bc7\u7814\u7a76\uff0c\u4ee5\u88f8\u9f20\u76ae\u819a\u70ba\u6a21\u578b\uff0c\u6e2c\u5f97\u98db\u68ad\u96f7\u5c04\u9020\u6210\u7684\u5fae\u901a\u9053\u5728\u7167\u5c04\u5f8c\u7d04\u5341\u516d\u5c0f\u6642\u6062\u5fa9\u5c4f\u969c\u529f\u80fd\u3002\u9019\u500b\u7d50\u679c\u4f86\u81ea\u52d5\u7269\u5be6\u9a57\uff0c\u4eba\u81c9\u76ae\u819a\u548c\u5be6\u969b\u80fd\u91cf\u8a2d\u5b9a\u4e26\u4e0d\u5b8c\u5168\u76f8\u540c\uff0c\u6240\u4ee5\u6211\u5011\u53ea\u628a\u9019\u500b\u6578\u5b57\u7576\u4f5c\u300c\u901a\u9053\u9589\u5408\u81f3\u5c11\u8981\u534a\u5929\u4ee5\u4e0a\u300d\u7684\u65b9\u5411\u53c3\u8003\uff0c\u5be6\u52d9\u4e0a\u7684\u5efa\u8b70\u6703\u4fdd\u5b88\u4e00\u4e9b\u3002<\/p>\n<h2>\u4e0d\u7834\u8868\u9762\u7684\u7642\u7a0b\uff1a\u7f8e\u7248\u97f3\u6ce2\u3001\u9cf3\u51f0\u96fb\u6ce2\u3001\u7d22\u592b\u6ce2<\/h2>\n<p>\u8d85\u97f3\u6ce2\u8207\u5c04\u983b\u62c9\u63d0\u7684\u80fd\u91cf\uff0c\u662f\u5f80\u771f\u76ae\u5c64\u4ee5\u4e0b\u6216\u7b4b\u819c\u5c64\u9001\uff0c\u8868\u5c64\u89d2\u8cea\u4e0d\u6703\u88ab\u6253\u958b\u3002\u8853\u5f8c\u51fa\u73fe\u7684\u7d05\u816b\u662f\u71b1\u80fd\u9020\u6210\u7684\u6b63\u5e38\u53cd\u61c9\u3002<\/p>\n<p>\u9019\u985e\u53cd\u61c9\u7dad\u6301\u591a\u4e45\uff0c\u6709\u56de\u9867\u6587\u737b\u53ef\u4ee5\u53c3\u8003\u3002\u5b78\u8853\u671f\u520a\u300aApplied Sciences\u300b2025\u5e74\u520a\u767b\u7684\u4e00\u7bc7HIFU\u7f8e\u5bb9\u7642\u7a0b\u4f75\u767c\u75c7\u56de\u9867\u6307\u51fa\uff0c\u591a\u6578\u4f75\u767c\u75c7\u5c6c\u65bc\u66ab\u6642\u6027\u7684\u7d05\u6591\u3001\u816b\u8139\u8207\u4e0d\u9069\u611f\uff0c\u901a\u5e38\u5728\u6578\u5c0f\u6642\u5230\u6578\u5929\u5167\u81ea\u884c\u7de9\u89e3\uff0c\u4e0d\u9700\u8981\u984d\u5916\u91ab\u7642\u8655\u7f6e\u3002<\/p>\n<p>\u6211\u5011\u745e\u8349\u9662\u5340\u5c0d\u9019\u985e\u7642\u7a0b\u7684\u8aaa\u660e\u662f\u9019\u6a23\u7684\uff1a\u7d05\u816b\u9084\u660e\u986f\u7684\u6642\u5019\uff0c\u7528\u624b\u6307\u6216\u4e7e\u6de8\u7684\u7c89\u64b2\u8f15\u62cd\u4e0a\u599d\uff0c\u4e0d\u8981\u7528\u5237\u5177\u4f86\u56de\u63a8\u62b9\u3002\u6469\u64e6\u5c0d\u9084\u6b98\u7559\u71b1\u80fd\u7684\u76ae\u819a\u662f\u4e0d\u5fc5\u8981\u7684\u523a\u6fc0\uff0c\u6240\u4ee5\u7576\u5929\u63a8\u3001\u62b9\u3001\u6309\u58d3\u9019\u985e\u52d5\u4f5c\u5148\u907f\u514d\u3002\u5982\u679c\u7642\u7a0b\u4e2d\u642d\u914d\u4e86\u5c40\u90e8\u9ebb\u9189\u6ce8\u5c04\uff0c\u816b\u8139\u53ef\u80fd\u62d6\u5f97\u7a0d\u9577\uff0c\u5efa\u8b70\u7559\u5230\u9694\u5929\u518d\u4e0a\u599d\u3002<\/p>\n<h2>\u7559\u4e0b\u5fae\u901a\u9053\u7684\u7642\u7a0b\uff1a\u55ac\u96c5\u9732\u9ed1\u74f6\u3001Skinvive\u3001\u9ec3\u91d1\u5fae\u91dd<\/h2>\n<p>\u55ac\u96c5\u9732\u9ed1\u74f6\u3001Skinvive\u9019\u985e\u6ce8\u5c04\u578b\u4fdd\u990a\u91dd\uff0c\u4ee5\u53ca\u9ec3\u91d1\u5fae\u91dd\uff08\u5c04\u983b\u5fae\u91dd\uff09\uff0c\u6703\u5728\u76ae\u819a\u4e0a\u9020\u51fa\u5be6\u969b\u7684\u5fae\u5c0f\u5b54\u6d1e\u3002\u5b54\u6d1e\u6df1\u5ea6\u3001\u6578\u91cf\uff0c\u4ee5\u53ca\u6ce8\u5c04\u7269\u7684\u9ecf\u7a20\u5ea6\uff0c\u6c7a\u5b9a\u7d05\u816b\u8207\u5fae\u816b\u7dad\u6301\u7684\u6642\u9593\u3002<\/p>\n<p>\u9019\u500b\u968e\u6bb5\u592a\u65e9\u5316\u599d\u6709\u5169\u500b\u554f\u984c\u3002\u7b2c\u4e00\uff0c\u9084\u6c92\u5b8c\u5168\u9589\u5408\u7684\u6ce8\u5c04\u9ede\uff0c\u53ef\u80fd\u8b93\u5237\u5177\u6216\u7c89\u64b2\u4e0a\u7684\u7d30\u83cc\u9032\u5165\u3002\u7b2c\u4e8c\uff0c\u63a8\u52fb\u599d\u5bb9\u6240\u9700\u8981\u7684\u58d3\u529b\uff0c\u6703\u76f4\u63a5\u50b3\u5230\u9084\u6c92\u5b9a\u578b\u7684\u6ce8\u5c04\u7269\u4e0a\u3002<\/p>\n<p>\u56e0\u6b64\u6211\u5011\u745e\u8349\u9662\u5340\u5c0d\u9019\u985e\u7642\u7a0b\u7684\u5efa\u8b70\u662f\uff0c\u7642\u7a0b\u7576\u5929\u4e0d\u4e0a\u8272\u599d\uff0c\u9694\u5929\u65e9\u4e0a\u518d\u958b\u59cb\u3002\u5982\u679c\u7576\u5929\u665a\u4e0a\u5c31\u6709\u9700\u8981\u898b\u4eba\u7684\u884c\u7a0b\uff0c\u53ef\u4ee5\u5728\u4e0d\u76f4\u63a5\u8986\u84cb\u6ce8\u5c04\u90e8\u4f4d\u7684\u7bc4\u570d\u5167\u5c11\u91cf\u4f7f\u7528\uff0c\u4e26\u4e14\u7528\u4e7e\u6de8\u7684\u7c89\u64b2\u3002\u8abf\u6574\u7642\u7a0b\u9806\u5e8f\u4e5f\u662f\u4e00\u500b\u65b9\u6cd5\uff0c\u4f8b\u5982\u628a\u55ac\u96c5\u9732\u9ed1\u74f6\u5b89\u6392\u5728\u56de\u7a0b\u524d\u4e00\u5929\u4e0b\u5348\uff0c\u73ed\u6a5f\u4e0a\u672c\u4f86\u5c31\u4e0d\u9700\u8981\u5316\u599d\uff0c\u6062\u5fa9\u6642\u9593\u81ea\u7136\u5c31\u7559\u51fa\u4f86\u4e86\u3002<\/p>\n<p>\u8089\u6bd2\u687f\u83cc\u7d20\u7684\u6ce8\u5c04\u9ede\u4e5f\u6703\u6709\u5fae\u5c0f\u958b\u53e3\uff0c\u4e0d\u904e\u901a\u9053\u6dfa\u3001\u7bc4\u570d\u5c0f\uff0c\u6062\u5fa9\u6bd4\u8f03\u5feb\u3002\u6bd4\u8d77\u5316\u599d\u6642\u9593\uff0c\u8853\u5f8c\u907f\u514d\u6469\u64e6\u6216\u6309\u58d3\u81c9\u90e8\u66f4\u91cd\u8981\u3002<\/p>\n<h2>\u8272\u7d20\u96f7\u5c04\u8207\u525d\u96e2\u6027\u96f7\u5c04\uff0c\u7b97\u6cd5\u4e0d\u4e00\u6a23<\/h2>\n<p>\u76ae\u79d2\u96f7\u5c04\u8207\u98db\u68ad\u96f7\u5c04\u6c92\u8fa6\u6cd5\u5957\u7528\u4e0a\u9762\u5169\u7a2e\u6642\u9593\u8868\u3002\u8868\u5c64\u7d30\u80de\u84b8\u767c\u6216\u5f62\u6210\u5fae\u5c0f\u75c2\u76ae\uff0c\u75c2\u76ae\u4ee3\u8b1d\u7684\u904e\u7a0b\u4e2d\uff0c\u76ae\u819a\u6b63\u5728\u518d\u4e0a\u76ae\u5316\u3002\u524d\u9762\u63d0\u5230\u7684\u91cf\u6e2c\u7814\u7a76\u88e1\uff0c\u5c4f\u969c\u56de\u5230\u8853\u524d\u6c34\u6e96\u8981\u82b1\u7d04\u4e00\u9031\uff0c\u8b1b\u7684\u5c31\u662f\u9019\u500b\u968e\u6bb5\u3002<\/p>\n<p>\u9019\u6bb5\u6642\u9593\u5982\u679c\u7528\u7c89\u5e95\u84cb\u7d05\uff0c\u5169\u500b\u98a8\u96aa\u6703\u758a\u52a0\u5728\u4e00\u8d77\uff1a\u611f\u67d3\u98a8\u96aa\u9084\u5728\u7684\u72c0\u614b\u4e0b\u591a\u4e86\u4e00\u5c64\u7570\u7269\uff0c\u800c\u6e05\u9664\u75c2\u76ae\u9019\u500b\u52d5\u4f5c\u672c\u8eab\u5c31\u662f\u984d\u5916\u7684\u7269\u7406\u523a\u6fc0\u3002\u5982\u679c\u662f\u590f\u5929\u66ec\u9ed1\u5f8c\u63a5\u53d7\u8272\u7d20\u96f7\u5c04\uff0c\u9084\u8981\u4e00\u4f75\u8003\u616e\u767c\u708e\u5f8c\u8272\u7d20\u6c89\u6fb1\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p>\u6211\u5011\u5b89\u6392\u77ed\u671f\u505c\u7559\u60a3\u8005\u7684\u7642\u7a0b\u7d44\u5408\u6642\uff0c\u82e5\u8981\u7d0d\u5165\u525d\u96e2\u6027\u8272\u7d20\u7642\u7a0b\uff0c\u4e00\u5b9a\u6703\u628a\u56de\u7a0b\u5f8c\u7684\u6062\u5fa9\u671f\u4e00\u8d77\u8a2d\u8a08\u9032\u53bb\u3002\u5982\u679c\u6574\u8d9f\u505c\u7559\u5fc5\u9808\u7dad\u6301\u80fd\u4e0a\u599d\u7684\u72c0\u614b\uff0c\u8272\u7d20\u76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