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u71b1\u523a\u6fc0\u3002\u300aFrontiers in Medicine\u300b\u57282025\u5e74\u520a\u51fa\u7684\u4e00\u9805\u9ec3\u91d1\u5fae\u91dd(\u7121\u7dda\u96fb\u6ce2)\u7814\u7a76\uff0c\u8a18\u9304\u6cbb\u7642\u5f8c24\u5c0f\u6642\u5167\u51fa\u73fe\u7684\u8f15\u5fae\u7d05\u6591\u8207\u816b\u8139\u5c6c\u65bc\u9810\u671f\u53cd\u61c9\uff0c\u4e26\u672a\u89c0\u5bdf\u5230\u611f\u67d3\u3001\u75a4\u75d5\u6216\u9577\u671f\u6301\u7e8c\u7684\u75bc\u75db\u3002\u4e0d\u904e\u4f9d\u7167\u6df1\u5ea6\u8207\u80fd\u91cf\u8a2d\u5b9a\u4e0d\u540c\uff0c\u5be6\u969b\u6062\u5fa9\u611f\u53d7\u4e5f\u6703\u6709\u843d\u5dee\uff0c\u9019\u5728\u8a3a\u9593\u76f8\u7576\u5e38\u898b\uff0c\u56e0\u6b64\u6211\u5728\u8a2d\u5b9a\u53c3\u6578\u524d\uff0c\u6703\u5148\u8a62\u554f\u8a2a\u5ba2\u5269\u4e0b\u7684\u505c\u7559\u5929\u6578\u3002<\/p>\n<h2>\u5169\u7a2e\u65b9\u5f0f\u6bd4\u8f03<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u9805\u76ee<\/th>\n<th>\u73bb\u5c3f\u9178\u6ce8\u5c04<\/th>\n<th>\u5916\u6ccc\u9ad4\uff0b\u5fae\u91dd\u50b3\u905e<\/th>\n<th>\u5916\u6ccc\u9ad4\uff0b\u9ec3\u91d1\u5fae\u91dd(\u7121\u7dda\u96fb\u6ce2)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u50b3\u905e\u8def\u5f91<\/td>\n<td>\u91dd\u7b52\u76f4\u63a5\u6ce8\u5165\u771f\u76ae<\/td>\n<td>\u7d93\u6dfa\u5c64\u5fae\u901a\u9053\u50b3\u905e<\/td>\n<td>\u88fd\u9020\u771f\u76ae\u901a\u9053\u4e26\u540c\u6b65\u50b3\u905e<\/td>\n<\/tr>\n<tr>\n<td>\u4f34\u96a8\u523a\u6fc0<\/td>\n<td>\u91dd\u523a<\/td>\n<td>\u91dd\u523a(\u6dfa\u5c64)<\/td>\n<td>\u91dd\u523a\u52a0\u4e0a\u7121\u7dda\u96fb\u6ce2\u71b1\u80fd<\/td>\n<\/tr>\n<tr>\n<td>\u5e38\u898b\u66ab\u6642\u53cd\u61c9<\/td>\n<td>\u6cdb\u7d05\u3001\u8f15\u5fae\u816b\u8139\u3001\u6ce8\u5c04\u9ede\u6de4\u9752<\/td>\n<td>\u6cdb\u7d05<\/td>\n<td>\u6cdb\u7d05\u3001\u816b\u8139\u3001\u707c\u71b1\u611f<\/td>\n<\/tr>\n<tr>\n<td>\u6062\u5fa9\u9ad4\u611f<\/td>\n<td>\u6cdb\u7d05\u816b\u8139\u7576\u5929\u5230\u5169\u5929\u5167\u3001\u82e5\u6709\u6de4\u9752\u52471\u52302\u9031<\/td>\n<td>\u4ee5\u6cdb\u7d05\u70ba\u4e3b\uff0c\u6062\u5fa9\u8f03\u5feb<\/td>\n<td>\u901a\u9053\u7652\u5408\u9700\u6578\u5929\u93ae\u5b9a\u671f<\/td>\n<\/tr>\n<tr>\n<td>\u9810\u671f\u8b8a\u5316<\/td>\n<td>\u6c34\u6f64\u8207\u5149\u6fa4\u611f\u8f03\u65e9\u51fa\u73fe<\/td>\n<td>\u50b3\u905e\u4fee\u5fa9\u8a0a\u865f\uff0c\u5206\u6b21\u6f38\u9032<\/td>\n<td>\u50b3\u905e\u4fee\u5fa9\u8a0a\u865f\u4e26\u4f34\u96a8\u71b1\u80fd\u91cd\u5851<\/td>\n<\/tr>\n<tr>\n<td>\u8b49\u64da\u6210\u719f\u5ea6<\/td>\n<td>\u985e\u5225\u7d9c\u8ff0\u8207\u81e8\u5e8a\u7814\u7a76\u5df2\u7d2f\u7a4d\uff0c\u64cd\u4f5c\u6d41\u7a0b\u5c1a\u672a\u6a19\u6e96\u5316<\/td>\n<td>\u7528\u8a5e\u8207\u54c1\u8cea\u7ba1\u7406\u6a19\u6e96\u4ecd\u5728\u6574\u7406\u968e\u6bb5<\/td>\n<td>\u5100\u5668\u7814\u7a76\u5df2\u7d2f\u7a4d\uff0c\u4f75\u7528\u6d41\u7a0b\u5c1a\u672a\u5b9a\u578b<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u8868\u683c\u4e2d\u7684\u6062\u5fa9\u671f\u6b04\u4f4d\uff0c\u7d9c\u5408\u4e86\u6587\u737b\u7d00\u9304\u8207\u6211\u5728\u8a3a\u9593\u7528\u4f86\u8aaa\u660e\u7684\u53c3\u8003\u7bc4\u570d\u3002\u500b\u9ad4\u5dee\u7570\u5b58\u5728\uff0c\u540c\u4e00\u985e\u5225\u5167\u4e5f\u6703\u56e0\u6ce8\u5c04\u91cf\u8207\u7bc4\u570d\u4e0d\u540c\u800c\u6709\u843d\u5dee\u3002<\/p>\n<h2>\u5f9e\u56de\u570b\u642d\u6a5f\u65e5\u5f80\u524d\u63a8\u7b97<\/h2>\n<p>\u505c\u7559\u6642\u9593\u6709\u9650\u6642\uff0c\u5b89\u6392\u9806\u5e8f\u770b\u7684\u662f\u5269\u9918\u5929\u6578\u80fd\u5426\u914d\u5408\u6062\u5fa9\u671f\uff0c\u5404\u9805\u7642\u7a0b\u7684\u6548\u679c\u5dee\u7570\u5247\u653e\u5728\u5176\u6b21\u8003\u91cf\u3002\u6211\u901a\u5e38\u9019\u6a23\u5b89\u6392:<\/p>\n<p>\u9996\u5148\u78ba\u8a8d\u56de\u570b\u642d\u6a5f\u65e5\uff0c\u4ee5\u53ca\u56de\u570b\u5f8c\u7dca\u63a5\u8457\u7684\u884c\u7a0b\u3002\u5982\u679c\u5a5a\u79ae\u3001\u62cd\u651d\u6216\u767c\u8868\u6703\u9019\u985e\u9700\u8981\u81c9\u90e8\u72c0\u614b\u7a69\u5b9a\u7684\u65e5\u5b50\u5df2\u7d93\u6392\u5b9a\uff0c\u9019\u500b\u65e5\u671f\u5c31\u662f\u57fa\u6e96\u7dda\u3002<\/p>\n<p>\u63a5\u8457\u770b\u5269\u4e0b\u7684\u5929\u6578\u3002\u5982\u679c\u505c\u7559\u53ea\u67092\u52303\u5929\uff0c\u800c\u6700\u5f8c\u4e00\u5929\u53c8\u6709\u91cd\u8981\u884c\u7a0b\uff0c\u6211\u4e0d\u6703\u52c9\u5f37\u5b89\u6392\u53ef\u80fd\u51fa\u73fe\u6de4\u9752\u7684\u6ce8\u5c04\u578b\u7642\u7a0b\u3002\u9019\u7a2e\u60c5\u6cc1\u4e0b\uff0c\u65b9\u5411\u6703\u8abf\u6574\u70ba\u4ee5\u6dfa\u5c64\u50b3\u905e\u70ba\u4e3b\uff0c\u642d\u914d\u4fdd\u6fd5\u8207\u93ae\u5b9a\uff0c\u6ce8\u5c04\u578b\u5247\u7559\u5230\u4e0b\u4e00\u6b21\u8a2a\u554f\u518d\u5b89\u6392\u3002<\/p>\n<p>\u5982\u679c\u505c\u75594\u5929\u4ee5\u4e0a\uff0c\u4e14\u62b5\u9054\u5f8c\u5c31\u80fd\u5b89\u6392\u6642\u9593\uff0c\u9806\u5e8f\u6703\u53cd\u904e\u4f86\u3002\u9700\u8981\u6062\u5fa9\u671f\u7684\u7642\u7a0b\u6392\u5728\u524d\u9762\uff0c\u5269\u4e0b\u7684\u5929\u6578\u7528\u4f86\u89aa\u81ea\u78ba\u8a8d\u72c0\u6cc1\u3002\u9019\u500b\u78ba\u8a8d\u7684\u6b65\u9a5f\u6211\u5f88\u770b\u91cd\uff0c\u56e0\u70ba\u6cbb\u7642\u7576\u5929\u7684\u81c9\u90e8\u72c0\u614b\uff0c\u5f80\u5f80\u4e0d\u5982\u5169\u5929\u5f8c\u7684\u81c9\u90e8\u72c0\u614b\u8cbc\u8fd1\u5be6\u969b\u7d50\u679c\u3002<\/p>\n<p>\u4e0a\u599d\u7684\u6642\u9593\u9ede\u4e5f\u5efa\u8b70\u63d0\u524d\u78ba\u8a8d\u3002\u591a\u6578\u60c5\u6cc1\u4e0b\u9694\u5929\u5c31\u80fd\u4e0a\u599d\uff0c\u4f46\u5982\u679c\u6709\u91cd\u8981\u884c\u7a0b\uff0c\u5efa\u8b70\u591a\u7559\u5e7e\u5929\u7de9\u885d\u3002\u9577\u9014\u98db\u884c\u5f8c\u81c9\u90e8\u5bb9\u6613\u6d6e\u816b\uff0c\u76ae\u819a\u72c0\u614b\u7684\u5224\u65b7\u672a\u5fc5\u6e96\u78ba\uff0c\u56e0\u6b64\u6211\u6703\u5efa\u8b70\u8a2a\u5ba2\u628a\u8aee\u8a62\u5b89\u6392\u5728\u62b5\u9054\u6b21\u65e5\u4e0a\u5348\uff0c\u800c\u4e0d\u662f\u62b5\u9054\u7576\u5929\u3002<\/p>\n<h2>\u6c5f\u5357\u5206\u9662\u5982\u4f55\u8a2d\u8a08\u9019\u5957\u6d41\u7a0b<\/h2>\n<p>\u5728\u8aee\u8a62\u4e2d\uff0c\u6211\u4e0d\u6703\u5148\u6c7a\u5b9a\u8981\u7528\u54ea\u4e00\u985e\u5225\u7684\u540d\u7a31\u3002\u5149\u6fa4\u4e0d\u8db3\u7684\u539f\u56e0\u7a76\u7adf\u662f\u6c34\u5206\u4e0d\u8db3\u3001\u819a\u8cea\u8207\u6bdb\u5b54\u554f\u984c\uff0c\u9084\u662f\u5f48\u6027\u4e0b\u964d\uff0c\u5019\u9078\u7642\u7a0b\u6703\u56e0\u6b64\u4e0d\u540c\uff0c\u800c\u5269\u4e0b\u7684\u505c\u7559\u5929\u6578\u53c8\u6703\u518d\u4e00\u6b21\u7e2e\u5c0f\u5019\u9078\u7bc4\u570d\u3002\u6240\u4ee5\uff0c\u9806\u5e8f\u6c38\u9060\u662f\u5148\u8a3a\u65b7\uff0c\u518d\u8a2d\u8a08\u7642\u7a0b\u3002<\/p>\n<p>\u6c5f\u5357\u5206\u9662\u4f4d\u65bcUH FLAT SIGNATURE\u6c5f\u5357\u5efa\u7bc9\u5167\uff0c\u4ee5\u98ef\u5e97\u9644\u5c6c\u8a2d\u65bd\u7684\u5f62\u5f0f\u904b\u4f5c\u3002\u7642\u7a0b\u7d50\u675f\u5f8c\uff0c\u8a2a\u5ba2\u53ef\u4ee5\u6e1b\u5c11\u6236\u5916\u66dd\u9732\uff0c\u76f4\u63a5\u56de\u5230\u623f\u9593\u8b93\u6cdb\u7d05\u7de9\u548c\uff0c\u9019\u5c0d\u7559\u6709\u6cdb\u7d05\u53cd\u61c9\u7684\u7642\u7a0b\u4f86\u8aaa\uff0c\u5728\u5b89\u6392\u884c\u7a0b\u6642\u6703\u5e36\u4f86\u5be6\u969b\u4e0a\u7684\u5dee\u5225\u3002\u7642\u7a0b\u65bc\u500b\u4eba\u8a3a\u5ba4\u9032\u884c\u3002<\/p>\n<p>\u6062\u5fa9\u671f\u7684\u7167\u8b77\u4e5f\u6703\u4e00\u4f75\u8aaa\u660e\u3002UHC\u98ef\u5e97\u623f\u5ba2\u53ef\u4ee5\u572830\u5206\u9418\u9ad8\u58d3\u6c27\u8259\u6216\u7dad\u4ed6\u547d\u9ede\u6ef4(IV 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