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of Cosmetic Dermatology\u300b\u767c\u8868\u7684\u7cfb\u7d71\u6027\u6587\u737b\u56de\u9867\u66a8\u7d71\u5408\u5206\u6790,\u53ea\u6536\u9304\u628aHA\u6ce8\u5165\u771f\u76ae\u5c64\u7684\u7d44\u5225\u8207\u751f\u7406\u98df\u9e7d\u6c34\u2027\u5b89\u6170\u5291\u2027\u672a\u8655\u7f6e\u7d44\u9032\u884c\u6bd4\u8f03\u7684\u96a8\u6a5f\u81e8\u5e8a\u8a66\u9a57\u3002\u7d50\u679c\u986f\u793a,HA\u6ce8\u5c04\u7d44\u7684\u6c34\u5206\u503c\u8207\u5149\u6fa4\u5ea6\u90fd\u51fa\u73fe\u986f\u8457\u6539\u5584\u3002\u76f8\u5c0d\u5730,\u7dca\u7dfb\u5ea6\u8207\u9ed1\u8272\u7d20\u6307\u6578\u8207\u5c0d\u7167\u7d44\u6c92\u6709\u986f\u8457\u5dee\u7570,\u4f5c\u8005\u7fa4\u4e5f\u6307\u51fa\u8981\u78ba\u8a8d\u9019\u90e8\u5206\u6548\u679c\u4ecd\u9700\u8981\u66f4\u591a\u7814\u7a76\u3002<\/p>\n<p>\u7f8e\u570b\u570b\u5bb6\u91ab\u5b78\u5716\u66f8\u9928PMC\u6536\u9304\u7684\u4e00\u9805\u4e2d\u570b\u591a\u4e2d\u5fc3\u96a8\u6a5f\u5c0d\u7167\u7814\u7a76\u63d0\u4f9b\u4e86\u66f4\u5177\u9ad4\u7684\u6578\u5b57\u3002456\u540d\u767b\u8a18\u8005\u4e2d\u6709439\u4eba\u5b8c\u6210\u7814\u7a76,\u6cbb\u7642\u7d44\u6bcf\u9694\u4e00\u500b\u6708\u63a5\u53d7\u4e00\u6b21\u8907\u5408\u578b\u73bb\u5c3f\u9178\u9209\u6eb6\u6db2\u6ce8\u5c04,\u5171\u4e09\u6b21,\u5c0d\u7167\u7d44\u5247\u672a\u63a5\u53d7\u4efb\u4f55\u65bd\u8853\u3002\u6cbb\u7642\u7d44\u7684\u6c34\u5206\u503c\u8207\u7dca\u7dfb\u5ea6\u6539\u5584,\u4e00\u8def\u7dad\u6301\u5230\u6700\u5f8c\u4e00\u6b21\u65bd\u8853\u5f8c\u4e09\u500b\u6708,\u4e0d\u826f\u53cd\u61c9\u767c\u751f\u7387\u70ba1.67%,\u4e14\u6c92\u6709\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u4e0d\u904e,\u9019\u9805\u7814\u7a76\u7684\u5c0d\u7167\u7d44\u662f\u672a\u8655\u7f6e\u800c\u975e\u5b89\u6170\u5291,\u4f7f\u7528\u7684\u4e5f\u662f\u55ae\u4e00\u8907\u5408\u88fd\u5291,\u56e0\u6b64\u4e0d\u80fd\u628a\u7d50\u679c\u76f4\u63a5\u5957\u7528\u5230\u6240\u6709\u6c34\u5149\u91dd\u7522\u54c1\u4e0a\u3002<\/p>\n<p>\u6211\u89e3\u8b80\u9019\u500b\u7d50\u679c\u7684\u65b9\u5f0f\u662f\u9019\u6a23\u7684\u3002\u5982\u679c\u4e3b\u8981\u56f0\u64fe\u662f\u76ae\u819a\u4e7e\u71e5\u3001\u6c92\u6709\u5149\u6fa4\u3001\u770b\u8d77\u4f86\u9eef\u6c89,HA\u6c34\u5149\u91dd\u662f\u6709\u5c0d\u61c9\u6e2c\u91cf\u5be6\u8b49\u652f\u6301\u7684\u9078\u9805\u3002\u5982\u679c\u671f\u5f85\u7684\u4e3b\u8981\u76ee\u7684\u662f\u7dca\u7dfb\u6216\u6539\u5584\u4e0b\u5782,\u7d71\u5408\u5206\u6790\u5c64\u7d1a\u7684\u8b49\u64da\u76ee\u524d\u9084\u6c92\u6709\u78ba\u8a8d\u9019\u90e8\u5206\u6548\u679c,\u4e86\u89e3\u9019\u4e00\u9ede\u4e4b\u5f8c\u518d\u6c7a\u5b9a\u6703\u6bd4\u8f03\u8e0f\u5be6\u3002<\/p>\n<h2>\u5b30\u5152\u91dd(PN\u2027PDRN):\u6709\u6bd4\u8f03\u7814\u7a76,\u4f46\u898f\u6a21\u504f\u5c0f<\/h2>\n<p>\u76f4\u63a5\u6bd4\u8f03PN\u8207HA\u7684\u7814\u7a76,\u6709Ye Jin Lee\u7b49\u4eba\u65bc2022\u5e74\u5728\u300aJournal of Dermatological Treatment\u300b\u767c\u8868\u7684\u96a8\u6a5f\u96d9\u76f2\u5206\u5272\u81c9\u8a66\u9a57\u300227\u4f4d\u53d7\u8a66\u8005\u7684\u4e00\u5074\u773c\u5468\u6ce8\u5c04PN\u586b\u5145\u5291,\u53e6\u4e00\u5074\u6ce8\u5c04\u672a\u4ea4\u806f\u578bHA\u586b\u5145\u5291,\u6bcf\u5169\u9031\u65bd\u6253\u4e00\u6b21,\u5171\u4e09\u6b21\u3002\u8996\u89ba\u985e\u6bd4\u91cf\u8868(VAS)\u8207\u6574\u9ad4\u7f8e\u5b78\u6539\u5584\u91cf\u8868(GAIS)\u5206\u6578\u5728\u5169\u7d44\u4e4b\u9593\u6c92\u6709\u986f\u8457\u5dee\u7570\u3002\u7dca\u7dfb\u5ea6\u8207\u6c34\u5206\u6539\u5584\u7387\u5728\u5169\u7d44\u90fd\u96a8\u6642\u9593\u4e0b\u964d,\u4f46PN\u5074\u504f\u9ad8;\u819a\u8cea\u7c97\u7cd9\u5ea6\u8207\u6bdb\u5b54\u9ad4\u7a4d\u7684\u6539\u5584\u7387\u540c\u6a23\u662fPN\u5074\u8f03\u9ad8\u3002\u771f\u76ae\u5bc6\u5ea6\u6539\u5584\u7387\u5728\u5169\u7d44\u4e4b\u9593\u6c92\u6709\u986f\u8457\u5dee\u7570\u3002\u9019\u500b\u7d50\u679c\u662f\u5728\u773c\u5468\u90e8\u4f4d\u3001\u5c0f\u898f\u6a21\u7814\u7a76\u7684\u689d\u4ef6\u4e0b\u5f97\u51fa\u7684,\u89e3\u8b80\u6642\u9700\u8981\u8003\u616e\u9019\u500b\u9650\u5236\u3002<\/p>\n<p>\u8b49\u64da\u7684\u6574\u9ad4\u898f\u6a21\u4e5f\u8981\u4e00\u4f75\u770b\u3002PMC\u6536\u9304\u7684\u4e00\u7bc7PN\u2027PDRN\u96a8\u6a5f\u81e8\u5e8a\u8a66\u9a57\u7cfb\u7d71\u6027\u6587\u737b\u56de\u9867,\u5408\u4f75\u76ae\u819a\u518d\u751f\u3001\u75a4\u75d5\u8207\u50b7\u53e3\u7652\u5408\u4e09\u500b\u4e3b\u984c,\u5171\u5206\u6790\u4e867\u7bc7\u7814\u7a76\u3001183\u540d\u53d7\u8a66\u8005,\u5404\u7bc7\u7814\u7a76\u5206\u6790\u4eba\u6578\u4ecb\u65bc10\u4eba\u523042\u4eba,\u8ffd\u8e64\u6642\u9593\u5247\u5f9e\u5169\u9031\u5230\u516d\u500b\u6708\u4e0d\u7b49\u3002\u76f8\u8f03\u65bcHA\u6c34\u5149\u7684\u7814\u7a76\u6578\u91cf\u8207\u4eba\u6578,\u9019\u500b\u898f\u6a21\u660e\u986f\u504f\u5c0f\u3002<\/p>\n<p>\u65bd\u8853\u6642\u7684\u611f\u53d7\u4e5f\u6709\u5dee\u7570\u30022025\u5e74\u520a\u767b\u65bc\u300aAesthetic Plastic Surgery\u300b\u7684\u96a8\u6a5f\u5206\u5272\u81c9\u7814\u7a76\u4f5c\u8005\u7fa4\u6307\u51fa,PN\u586b\u5145\u5291\u56e0\u70ba\u518d\u751f\u7279\u6027\u800c\u88ab\u5ee3\u6cdb\u4f7f\u7528,\u4f46\u6ce8\u5c04\u6642\u7684\u75bc\u75db\u611f\u662f\u4e3b\u8981\u7f3a\u9ede\u3002\u9e97\u73e0\u862d\u9ed1\u76d2\u3001\u9e97\u73e0\u862d\u7d05\u76d2\u9019\u985ePN\u88fd\u5291\u5c6c\u65bc\u540c\u4e00\u985e\u5225,\u56e0\u6b64\u75bc\u75db\u8655\u7406\u65b9\u5f0f\u4e5f\u662f\u8aee\u8a62\u6642\u503c\u5f97\u4e00\u4f75\u78ba\u8a8d\u7684\u9805\u76ee\u3002<\/p>\n<h2>\u5916\u6ccc\u9ad4:\u8ac7\u6548\u679c\u4e4b\u524d,\u5148\u78ba\u8a8d\u6838\u51c6\u7bc4\u7587<\/h2>\n<p>\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40(FDA)\u57282019\u5e7412\u67086\u65e5\u7684\u516c\u544a\u4e2d\u6307\u51fa,\u7f8e\u570b\u5167\u5e03\u62c9\u65af\u52a0\u5dde\u6709\u591a\u540d\u60a3\u8005\u5728\u63a5\u53d7\u6a19\u699c\u542b\u5916\u6ccc\u9ad4\u7684\u672a\u6838\u51c6\u7522\u54c1\u5f8c,\u901a\u5831\u51fa\u73fe\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u540c\u4e00\u4efd\u516c\u544a\u4e5f\u8aaa\u660e,\u76ee\u524d\u6c92\u6709\u4efb\u4f55\u6838\u51c6\u4e0a\u5e02\u7684\u5916\u6ccc\u9ad4\u7522\u54c1,\u800c\u7528\u65bc\u6cbb\u7642\u75be\u75c5\u6216\u75c5\u75c7\u7684\u5916\u6ccc\u9ad4,\u5fc5\u9808\u4ee5\u85e5\u54c1\u2027\u751f\u7269\u88fd\u5291\u7684\u8eab\u5206\u7d93\u904e\u4e0a\u5e02\u524d\u5be9\u67e5\u8207\u6838\u51c6\u3002FDA\u7684\u518d\u751f\u91ab\u7642\u6d88\u8cbb\u8005\u8cc7\u8a0a\u9801\u9762\u4e5f\u5beb\u9053,\u6536\u5230\u904e\u8207\u5916\u6ccc\u9ad4\u5728\u5167\u7684\u672a\u6838\u51c6\u518d\u751f\u91ab\u7642\u7522\u54c1\u76f8\u95dc\u7684\u5931\u660e\u3001\u816b\u7624\u5f62\u6210\u3001\u611f\u67d3\u7b49\u901a\u5831\u3002<\/p>\n<p>\u97d3\u570b\u570b\u5167\u4e5f\u51fa\u73fe\u904e\u985e\u4f3c\u554f\u984c\u3002\u6839\u64da2022\u5e74\u7684\u65b0\u805e\u5831\u5c0e,\u97d3\u570b\u570b\u6703\u4fdd\u5065\u798f\u7949\u59d4\u54e1\u6703\u5d14\u60e0\u82f1\u8b70\u54e1\u5728\u7576\u5e74\u7684\u570b\u653f\u76e3\u5bdf\u4e2d\u6307\u51fa,\u6ce8\u5165\u771f\u76ae\u5c6c\u65bc\u91ab\u7642\u884c\u70ba,\u4f46\u5916\u6ccc\u9ad4\u7522\u54c1\u537b\u662f\u4ee5\u5316\u599d\u54c1\u7684\u8eab\u5206\u767b\u8a18\u65bc\u98df\u54c1\u85e5\u54c1\u5b89\u5168\u8655\u3002\u5831\u5c0e\u63d0\u5230,\u5316\u599d\u54c1\u767b\u8a18\u4e0d\u9700\u8981\u7d93\u904e\u54c1\u9805\u8a31\u53ef\u7a0b\u5e8f\u6216\u88fd\u9020\u904e\u7a0b\u7684\u6ec5\u83cc\u6a19\u6e96\u5be9\u67e5,\u6ce8\u5c04\u65b9\u5f0f\u4f7f\u7528\u5f8c\u7684\u5f71\u97ff\u7576\u6642\u4e26\u672a\u7372\u5f97\u78ba\u8a8d,\u4e5f\u5df2\u6536\u5230\u75a4\u75d5\u3001\u767c\u7d05\u7b49\u526f\u4f5c\u7528\u901a\u5831\u3002\u5927\u97d3\u76ae\u819a\u79d1\u91ab\u5e2b\u6703\u540c\u5e74\u4e5f\u5411\u6703\u54e1\u767c\u51fa\u63d0\u9192\u6ce8\u610f\u7684\u516c\u544a\u3002<\/p>\n<p>\u6cd5\u898f\u72c0\u6cc1\u53ef\u80fd\u56e0\u7522\u54c1\u8207\u6642\u9593\u9ede\u800c\u4e0d\u540c\u3002\u56e0\u6b64,\u5982\u679c\u8003\u616e\u4f7f\u7528\u5916\u6ccc\u9ad4,\u5efa\u8b70\u5728\u8aee\u8a62\u6642\u76f4\u63a5\u78ba\u8a8d\u7522\u54c1\u540d\u7a31\u3001\u8a72\u7522\u54c1\u5c6c\u65bc\u85e5\u54c1\u9084\u662f\u5316\u599d\u54c1,\u4ee5\u53ca\u662f\u5916\u7528\u9084\u662f\u6ce8\u5c04\u65b9\u5f0f\u3002\u5224\u65b7\u73bb\u7483\u808c\u6548\u679c,\u662f\u78ba\u8a8d\u5b8c\u9019\u4e9b\u4e4b\u5f8c\u7684\u4e8b\u3002<\/p>\n<h2>\u4f9d\u819a\u6cc1\u7be9\u9078\u5019\u9078\u9805\u76ee\u7684\u512a\u5148\u9806\u5e8f<\/h2>\n<p>\u540c\u6a23\u4ee5\u73bb\u7483\u808c\u70ba\u76ee\u6a19,\u819a\u6cc1\u4e0d\u540c,\u51fa\u767c\u9ede\u4e5f\u4e0d\u4e00\u6a23\u3002\u4f9d\u7814\u7a76\u6e2c\u91cf\u7684\u9805\u76ee\u6574\u7406,\u5927\u81f4\u5982\u4e0b:<\/p>\n<ol>\n<li><strong>\u4e7e\u71e5\u9eef\u6c89\u3001\u7f3a\u4e4f\u5149\u6fa4<\/strong>:HA\u6c34\u5149\u91dd\u662f\u53ef\u4ee5\u512a\u5148\u8003\u616e\u7684\u9078\u9805,\u7d71\u5408\u5206\u6790\u4e2d\u78ba\u8a8d\u6539\u5584\u7684\u9805\u76ee\u6b63\u662f\u6c34\u5206\u503c\u8207\u5149\u6fa4\u5ea6\u3002<\/li>\n<li><strong>\u819a\u8cea\u7c97\u7cd9\u3001\u773c\u5468\u7d30\u7d0b\u6216\u6bdb\u5b54\u660e\u986f<\/strong>:\u53ef\u4ee5\u628aPN\u7cfb\u5217\u5217\u5165\u5019\u9078,\u4f46\u8207HA\u6bd4\u8f03\u7684\u5be6\u8b49,\u76ee\u524d\u50c5\u9650\u65bc\u773c\u5468\u90e8\u4f4d\u7684\u5c0f\u898f\u6a21\u7814\u7a76\u3002<\/li>\n<li><strong>\u7dca\u7dfb\u6216\u4e0b\u5782\u662f\u4e3b\u8981\u56f0\u64fe<\/strong>:\u4e09\u7a2e\u9078\u9805\u5728\u9019\u500b\u76ee\u7684\u4e0a\u7684\u5be6\u8b49\u90fd\u9084\u4e0d\u5920\u5145\u5206,\u5982\u679c\u5df2\u7d93\u51fa\u73fe\u4e0b\u5782,\u5efa\u8b70\u9023\u540c\u62c9\u63d0\u985e\u65bd\u8853\u4e00\u8d77\u63a5\u53d7\u8a3a\u65b7\u8a55\u4f30\u3002<\/li>\n<li><strong>\u88ab\u5efa\u8b70\u4f7f\u7528\u5916\u6ccc\u9ad4<\/strong>:\u6bd4\u8d77\u6548\u679c\u6bd4\u8f03,\u5148\u78ba\u8a8d\u7522\u54c1\u7684\u6838\u51c6\u7bc4\u7587\u8207\u6295\u4e88\u65b9\u5f0f\u3002<\/li>\n<\/ol>\n<p>\u5982\u679c\u5728\u9996\u723e\u505c\u7559\u7684\u6642\u9593\u4e0d\u9577,\u884c\u7a0b\u5b89\u6392\u4e5f\u6703\u5f71\u97ff\u9078\u64c7\u3002\u4ee5\u91dd\u5177\u6ce8\u5165\u771f\u76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FLAT 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